Preheat your oven to 350°F (175°C). Grease an 8½ x 4½-inch loaf pan or line it with parchment paper, letting it hang over the long sides for easy removal.
In a large bowl, whisk together the Greek yogurt (or sour cream), oil, brown sugar, granulated sugar, egg, lemon zest, and vanilla extract for about 1 minute until the mixture is pale and creamy.
Add the flour, baking soda, and salt directly to the wet mixture. Gently fold with a wooden spoon or spatula until just combined. Stop when you still see some dry streaks - don't overmix.
In a small bowl, toss the blueberries with 1 tablespoon of flour until completely coated. This prevents them from sinking and creating soggy spots.
Add the flour-coated blueberries (including any leftover flour) to the batter. Fold gently with just a few strokes to distribute the berries throughout without smashing them.
Pour the batter into the prepared loaf pan and spread it evenly. Sprinkle the 2 tablespoons of coarse sugar generously over the top.
Bake for 50-55 minutes, until a toothpick inserted in the center comes out clean or with just a few moist crumbs. The top should be golden brown with a crackling sugar crust.
Remove from oven and let the bread cool in the pan for 10 minutes on a wire rack.
Use the parchment overhangs to lift the bread out of the pan. Transfer to the wire rack and let cool completely for about 1 hour before slicing. This ensures clean slices that show off the blueberry pockets.