Season the beef slices generously with salt and pepper.
In a bowl, mix breadcrumbs, Parmesan, garlic, parsley, oregano, salt, and pepper.
Place about 2 tablespoons of filling on each beef slice, roll tightly, and secure with toothpicks or kitchen twine.
Brown the rolls in 1/4 cup olive oil in a skillet over medium-high heat, about 6-8 minutes.
In the same skillet, sauté onion and garlic in 1 tablespoon olive oil until fragrant, about 3 minutes.
Add crushed tomatoes, basil, oregano, salt, and pepper. Simmer for 10 minutes.
Return beef rolls to the sauce, cover, and simmer on low heat for 2 hours, turning occasionally.
Serve over pasta, polenta, or with crusty bread.